GIInger predicts homologous recombination deficiency and patient response to PARPi treatment from shallow genomic profiles

Christian Pozzorini , Gregoire Andre , Tommaso Coletta , Adrien Buisson , Jonathan Bieler , Loïc Ferrer , Rieke Kempfer , Pierre Saintigny (1, 2, 3) , Alexandre Harlé , Davide Vacirca , Massimo Barberis , Pauline Gilson , Cristin Roma , Alexandra Saitta , Ewan Smith , Floriane Consales Barras , Lucia Ripol , Martin Fritzsche , Ana Claudia Marques , Amjad Alkodsi , Ray Marin , Nicola Normanno , Christoph Grimm , Leonhard Müllauer , Philipp Harter , Sandro Pignata , Antonio Gonzalez-Martin , Ursula Denison , Keiichi Fujiwara , Ignace Vergote , Nicoletta Colombo , Adrian Willig , Eric Pujade-Lauraine , Pierre-Alexandre Just , Isabelle Ray-Coquard , Zhenyu Xu

1 UCBL - Université Claude Bernard Lyon 1
2 Centre Léon Bérard [Lyon]
3 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon

Highlights d Implementation hurdles restrict adoption of HRD testing, a PARPi response biomarker d GIInger leverages HRD-induced genome scarring from lowcoverage sequencing data d GIInger accurately stratifies ovarian cancer patients for PARPi treatment d GIInger is cost effective and seamlessly integrates into BRCA status workflows Authors

Domains: Cancer

Christian Pozzorini, Gregoire Andre, Tommaso Coletta, Adrien Buisson, Jonathan Bieler, et al.. GIInger predicts homologous recombination deficiency and patient response to PARPi treatment from shallow genomic profiles. Cell Reports Medicine, 2023, 4, ⟨10.1016/j.xcrm.2023.101344⟩. ⟨hal-04400735⟩