Protein kinase C signaling dysfunction in von Willebrand disease (p.V1316M) type 2B platelets
Abstract
Key Points In VWD (p.V1316M) type 2B, the VWF–GPIb interaction alters the sustained PKC-mediated pathway of Rap1 activation. VWF/p.V1316M expression in mice causes multiple platelet dysfunctions, including significant ADAM17-independent shedding of GPIbα.
Domains
Life Sciences [q-bio]
Origin : Files produced by the author(s)