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Nanostructured metallic supports as ultrasensitive platforms for sequential plasmonic and acoustic detection of biomolecules

Abstract : The presence of various types of biomolecules in body fluids is monitored using either standard technologies which are time consuming, sophisticated and required costly instrumentation (e.g. chromatography) or by using advances (miniaturized) technologies like biosensor devices that are simple, rapid as response-time, less expensive, portable and highly sensitive and selective over the interfering compounds. Between different types of biosensors, quartz crystal microbalance (QCM) and localized surface resonance (LSPR) technologies enable a label-free detection of biorecognition events (e.g. antigen-antibody specific/non-specific interactions) in only few minutes/seconds. Herein, new plasmonic and acoustic biosensors based on high annealing temperature protocols and on a drop-deposition procedure as rapid sequential detection of different types of biomolecules (e.g. cholera toxin-CT, atrazine, bovine serum albumin-BSA) on a single micro-structured quartz crystal/gold-modified glass supports are discussed. The biomolecules are optically detected in the range of 1 ng/mL CT, 50 pg/mL atrazine and 1 ng/mL BSA, respectively.
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Conference papers
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https://hal-utt.archives-ouvertes.fr/hal-02434812
Contributor : Daniel Gavrysiak <>
Submitted on : Friday, January 10, 2020 - 12:50:46 PM
Last modification on : Thursday, April 2, 2020 - 2:26:18 PM

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Rodica Elena Ionescu. Nanostructured metallic supports as ultrasensitive platforms for sequential plasmonic and acoustic detection of biomolecules. European Biotechnology Congress, May 2015, Bucharest, Romania. pp.S27, ⟨10.1016/j.jbiotec.2015.06.071⟩. ⟨hal-02434812⟩

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