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Microwave spectroscopic detection of human Hsp70 protein on annealed gold nanostructures on ITO glass strips

Abstract : Conductive indium-tin oxide (ITO) and non-conductive glass substrates were successfully modified with embedded gold nanoparticles (AuNPs) formed by controlled thermal annealing at 550 °C for 8 h in a preselected oven. The authors characterized the formation of AuNPs using two microscopic techniques: scanning electron microscopy (SEM) and atomic force microscopy (AFM). The analytical performances of the nanostructured-glasses were compared regarding biosensing of Hsp70, an ATP-driven molecular chaperone. In this work, the human heat-shock protein (Hsp70), was chosen as a model biomarker of body stress disorders for microwave spectroscopic investigations. It was found that microwave screening at 4 GHz allowed for the first time the detection of 12 ng/µL/cm2 of Hsp70.
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https://hal-utt.archives-ouvertes.fr/hal-02365657
Contributor : Rodica Elena Ionescu <>
Submitted on : Friday, November 15, 2019 - 2:42:53 PM
Last modification on : Monday, December 9, 2019 - 2:10:05 PM

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Rodica Elena Ionescu, Raphael Selon, Nicolas Pocholle, Lan Zhou, Anna Rumyantseva, et al.. Microwave spectroscopic detection of human Hsp70 protein on annealed gold nanostructures on ITO glass strips. Biosensors, MDPI, 2018, 8 (4), pp.1-10. ⟨10.3390/bios8040118⟩. ⟨hal-02365657⟩

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