Detecting a Zeptogram of Pyridine with a Hybrid Plasmonic–Photonic Nanosensor

Abstract : Thanks to their small sensing volume, nanosensors based on localized surface plasmon resonances (LSPR) allow the detection of minute amounts of analytes, down to the single-molecule limit. However, the detected analytes are often large molecules, such as proteins. The detection of small molecules remains largely unexplored. Here, we use a hybrid photonic–plasmonic nanosensor to detect a small target molecule (pyridine). The sensor’s design is based on a dielectric photonic microstructure acting as an antenna, which efficiently funnels light toward a plasmonic transducer and enhances the detection efficiency. This sensor exhibits a limit of detection as small as 10–14 mol L–1. Using a calibration procedure based on electrodynamical numerical simulations, we compute the number of detected molecules. This yields a limit of detection in mass of 4 zeptograms (1 zg = 10–21 g), a record value for plasmonic molecular sensors. Our system can hence be seen as an optical molecular weighing scale, enabling room temperature detection of mass at the zeptogram scale.
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https://hal-utt.archives-ouvertes.fr/hal-02301706
Contributor : Daniel Gavrysiak <>
Submitted on : Monday, September 30, 2019 - 4:11:35 PM
Last modification on : Tuesday, October 1, 2019 - 1:32:27 AM

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Julien Proust, Jérôme Martin, Davy Gérard, Jean-Louis Bijeon, Jerome Plain. Detecting a Zeptogram of Pyridine with a Hybrid Plasmonic–Photonic Nanosensor. ACS Sensors, American Chemical Society, 2019, 4 (3), pp.586-594. ⟨10.1021/acssensors.8b01068⟩. ⟨hal-02301706⟩

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