Optimization of a Synthetic Step Using a Design of Experiments Approach: Application to a Late-Stage Radiolabeling Method by Aluminium-[18F]Fluoride Coordination

Carine San (1, 2) , Meriem Beddek (3) , Fabienne Dioury (1) , Nicolas Vignal (2) , Benoit Hosten (2) , Maurice Pillet (4) , Laure Sarda-Mantel (5) , Marc Port (1)

1 GBCM - Laboratoire Génomique, bioinformatique et chimie moléculaire
2 AP-HP - Hopital Saint-Louis [AP-HP]
3 GHU AP-HP Nord - Université Paris Cité
4 SYMME - Laboratoire SYstèmes et Matériaux pour la MEcatronique
5 Hôpital Lariboisière-Fernand-Widal [APHP]

Mots clés: Coordination Chemistry; Aluminium; Chelating Agents/chemistry; Fluorine 18; Design of experiments DoE

Domaines: Radiochimie; Chimie de coordination; Méthodologie [stat.ME]

Carine San, Meriem Beddek, Fabienne Dioury, Nicolas Vignal, Benoit Hosten, et al.. Optimization of a Synthetic Step Using a Design of Experiments Approach: Application to a Late-Stage Radiolabeling Method by Aluminium-[18F]Fluoride Coordination. EFMC-ISMC 2022 _ XXVll EFMC International Symposium on Medicinal Chemistry, Sep 2022, Nice, France. ⟨hal-03776858⟩