The First Isoenzymatic Characterizations of the Leishmania Strains Responsible for Cutaneous Leishmaniasis in the Area of Annaba (Eastern Algeria)

Roukaya Mansouri (1) , Francine Pratlong (2, 3) , Fatma Bachi (4) , Boussad Hamrioui (5) , Jean-Pierre Dedet (3, 2)

1 UBMA - Université Badji Mokhtar [Annaba]
2 CNR-L - Centre National de Référence des Leishmanioses [CHRU Montpellier]
3 MIVEGEC - Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle
4 Institut Pasteur d'Algérie
5 CHU Nafissa Hamoud [Hussein Dey]

The epidemiological situation of cutaneous leishmaniasis in the region of Annaba (North Eastern Algeria) is explored for the first time. During a clinical survey carried out in the Annaba Hospital between 2004 and 2008, the parasitological study of lesions has revealed 259 positive cases (43.31%). Isoenzymatic identification of 16 strains isolated showed the presence of three Leishmania species and four zymodemes. The hypothesis of the presence of L. infantum is confirmed with two zymodemes, MON-1 and MON-24. The unexpected presence of L. major MON-25 certifies the substantial extension of this zoonotic form to the North. The isolation of L.killicki, whose presence was unsuspected, reiterated the interest of eco-epidemiological analysis of households affected by the disease. Moreover, it is a new zymodeme never isolated so far, the MON-306.

Mots clés: Annaba; Algeria; Cutaneaous leishmaniases; Leishmania infantum; Leishmania killicki; Leishmania major

Domaines: Maladies infectieuses; Dermatologie; Parasitologie; Santé publique et épidémiologie

Roukaya Mansouri, Francine Pratlong, Fatma Bachi, Boussad Hamrioui, Jean-Pierre Dedet. The First Isoenzymatic Characterizations of the Leishmania Strains Responsible for Cutaneous Leishmaniasis in the Area of Annaba (Eastern Algeria). The Open Conference Proceedings Journal, 2012, 3 (suppl 2-M2), pp.6-11. ⟨10.2174/1876326X01203020006⟩. ⟨hal-03543534⟩